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Initially developed for diabetes, they are now widely used for obesity treatment and are under investigation for a wide range of other conditions, from kidney and heart disease to addiction to dementia

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Another study found that the analogous plasticizer, bisphenol F (BPF), dose-dependently increased expression of glycolytic enzymes (e.g., HIF-1, GLUT1, PKM2), lactate production, and glucose consumption, and increased the secretion of pro-inflammatory cytokines (e.g., TNF-, IL-1, and IL-6) in murine RAW 264.7 cells

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It works best as a complement to a healthy diet and regular exercise program

Instead, reducing protein intake may be more effective at lowering IGF-1 levels