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Maridebart cafraglutide (a monthly GLP-1 in trials) addresses this by using an IgG scaffold to harness the natural FcRn recycling pathway for around a two-week half-life

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The selective mechanism is why Melanotan-1 remains the only melanotropic peptide with FDA approval for any indication

For instance, replacing problematic functional groups, such as the carboxylic acid group in danuglipron, with alternative structures has shown promise

Injection of contaminated medication could result in local injection site infections