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Timeline and Market Impact The benefits industry analysis suggests that while generic approvals may slip into late 2026, the eventual price reductions will significantly impact drug plan budgets across Canada

Evidence of past weight loss attempts: Some plans require proof of previous diet and exercise attempts before approving GLP-1s

A randomised controlled trial with 961 participants compared the impact of a once-weekly dose of 1mg or 2mg of semaglutide on blood glucose levels and weight loss for people living with type 2 diabetes

6.3 Clinical applications in cardiovascular disease prevention Recent American College of Cardiology/American Heart Association guidelines advocate for the use of GLP-1RAs in patients with T2DM at high risk of atherosclerotic cardiovascular disease (ASCVD), irrespective of well-controlled glucose levels, based on the clinical trials mandated by FDA-issued industry guidelines in December 2008 to assess the cardiovascular effects of new diabetic therapies (247)

Current Drug Delivery