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This localized interface failure rigorously precedes the subsequent pathological accumulation of cytosolic mtDNA and the downstream hyperactivation of the cGAS-STING pathway, proving that the disruption of TFAM-mediated organelle crosstalk is the primary initiator of sterile autoimmune pathology

We appreciate the funding support from National Heart Blood Lung Institute at the National Institutes of Health (NIH) award 1R15HL143545-01A1

However, more research is still required on Vitamin B12 supplements on cognitive function and memory

Ebrahimi-Fakhari, D., Wahlster, L., & McLean, P

Ketones and the heart: metabolic principles and therapeutic implications

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