FDA-labeled warnings include: Risk of thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) Pancreatitis (report severe abdominal pain, with or without vomiting) Gallbladder disease (including gallstones and cholecystitis) Acute kidney injury secondary to dehydration from gastrointestinal symptoms Hypoglycemia when used with insulin or insulin secretagogues (dose adjustments may be needed) Diabetic retinopathy complications in patients with type 2 diabetes and pre-existing retinopathy Suicidal behavior and ideation (monitor for depression or suicidal thoughts) Intestinal obstruction/ileus (particularly with severe constipation) These medications are contraindicated during pregnancy and should be discontinued at least two months before a planned pregnancy
Lin SK, Tsai SM, Huang JC, Lee SC, Wu SH, Wu SH, et al
By keeping an unopened vial refrigerated, away from light, and within the temperature range recommended by the manufacturer, you can ensure that it remains effective until the expiration date
L-:GB 1903.13-2016[S]
Thanks for sharing Lauren!
In rats, feeding activity and food intake decreased following intracerebroventricular injection of GLP-1, an effect counteracted by co-administration of a GLP-1 receptor antagonist (71, 72), suggesting central GLP-1 as a potent inhibitor of feeding