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The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11.79
Treatment of Drosophila flies with kynurenine pathway inhibitors and the NAD + precursors NR or NAM increased the lifespan of these animals, suggesting an advantage in combining different therapeutic strategies
Remarkably, GSH depletion significantly decreased the expression of these key fibrogenic factors under both chow and HFD conditions (Figure 3, A and B)
Gutniak M, Orskov C, Holst JJ, et al
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