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Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

Probucol, a lipid-lowering agent, also exhibits antioxidant properties that reduce intracellular oxidative stress and maintain normal cellular redox state by upregulating Nrf2 and GPX4 protein expression, thereby enhancing cardiomyocyte antioxidant capacity

Synaptic Neurosci

We hypothesized that increased oxidative stress resistance might be the cause of an unexpected change in the pathogenicity of gsh-px mutants

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