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Autophagy dysfunction has been linked to central sensitization in a nitroglycerin-induced chronic migraine model in mice (63)

Statements Author contributions YL: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Writing original draft, Writing review & editing

Individuals with Chronic Pain To reduce inflammation and alleviate discomfort from musculoskeletal conditions

The Benefits of Contrast Therapy Some people find alternating between ice and heat provides superior relief

Notably, the gut microbiome may impact mood and cognitive function via the gut-brain axis [283,284,285]

LGIT recommends consuming less than 50 g, or 4060 g, of low glycemic index (GI) carbohydrates per day, which accounts for 10% of total energy intake (61)