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Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial)

Mice in the cinchonine groups received 50 mg/kg or 100 mg/kg cinchonine by oral gavage twice a day

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Contact your GP, diabetes specialist nurse, or NHS 111 if: Headaches are persistent, worsening, or significantly impacting daily activities despite simple management measures You experience frequent hypoglycaemic episodes (blood glucose below 4 mmol/L) [31] [32] You have signs of dehydration such as reduced urine output, excessive thirst, or dizziness when standing Side effects are affecting medication adherence or quality of life You develop new or unusual symptoms that concern you Headaches follow a different pattern from any pre-existing headache disorder Healthcare professionals can assess whether headaches are likely related to GLP-1 therapy or require investigation for alternative causes

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