A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
Studies report 75% reduction of lipid peroxidation in gastric mucosa homogenates at concentrations between 10-100 mM
This helps in the restoration of normal circadian rhythm as melatonin secretion is a critical chemical that balances the sleep/wake cycle (6)
Glutathione is a powerful antioxidant that helps eliminate toxins in the body, thereby promoting general well-being
Also, because of Glutathione, the serum may have slightly sulfuric smell and less blue hue
This setup produced opposite PA signal changes when GSH was reduced, allowing for specific and sensitive detection [96]