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The phase 3 Exenatide-PD3 trial found no benefit over 96 weeks, with off-medication motor scores worsening in both arms and no significant difference between them (Vijiaratnam et al., 2025)
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Patients were treated with exenatide (14/23) or liraglutide (9/23) and GLP-1 RAs treatment was again connected to a wide range of weight loss, from 1.5 to 16 kg/m 2 in 10/14 cases, and an HbA1c improvement in 19/23 cases, without reported serious side effects (36)
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