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Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus

A receptor first understood as a pancreatic switch for insulin turned out to sit across circuits that govern reward, memory, mood, and movement, and the drugs that engage it have become some of the most-studied molecules in medicine

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In both studies, tesamorelin-treated patients completing the 26-week treatment period were re-randomized to blinded therapy with either daily placebo or 2 mg tesamorelin for an additional 26-week treatment period (Extension Phase) in order to assess maintenance of VAT reduction and to gather long-term safety data

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