A high proportion of body fat increases the risk of many different diseases, such as type 2 diabetes, cardiovascular disease, osteoarthritis and certain types of cancer (1)

References Nature Medicine (2014) Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity PMC (2024) Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions Frontiers in Pharmacology (2024) NNMT: a novel therapeutic target for metabolic syndrome PubMed (2021) LC-MS/MS assay for 5-amino-1-methylquinolinium: pharmacokinetic and oral bioavailability study ResearchGate (2021) Combined NNMT inhibition and reduced-calorie diet normalizes body composition in obese mice PMC (2022) Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice NMN.com / Scientific Reports Role of NNMT inhibition in muscle strength: enhanced grip strength with exercise Swolverine 5-Amino-1MQ mechanism, benefits, stacking and cycling guide PMC Subcutaneous drug injection review: pharmacologic considerations CDC Vaccine administration: subcutaneous route (angle/site

Much of the appetite suppression studies have occurred with GLP-1 which causes appetite suppression in a multifactorial way
Since overall food intake is reduced, the quality of your food matters more than ever
Corrigendum to nitric oxide signaling: classical, less classical, and nonclassical mechanisms. Free Radic Biol Med
That simplicity is worth its weight in gold when fatigue and low appetite make cooking feel impossible