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At week 36, the 12mg group showed the most dramatic eating behavior changes: Perceived hunger decreased by 2.4 points versus placebo Disinhibition improved by 2.6 points Dietary restraint increased by 3.3 points 100% of participants achieved at least 5% body weight loss by week 48 83% achieved 15% or greater weight loss Mean weight reduction reached 24.2% at 48 weeks These numbers represent the strongest weight loss and appetite-related outcomes ever recorded in clinical trials for any GLP-1 class medication
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In studies with rats, Tirzepatide and medicines that work like Tirzepatide caused thyroid tumors, including thyroid cancer
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