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In the Phase 2 trial published in the New England Journal of Medicine in 2023, participants on the highest dose of 12mg reported significant reductions in appetite and food intake within the first two weeks
In addition, switching from dulaglutide therapy to injectable semaglutide therapy has a weaker BW-reducing effect than switching from other GLP-1RAs [41]
The most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and abdominal discomfort, affecting more than 1 in 10 patients
Clinical trial data demonstrates that both agents can achieve substantial weight loss, with Retatrutide achieving up to 24% body weight reduction and Cagrilintide reaching over 20% when combined with semaglutide
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