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Metabolism 86 , 135144 (2018)

For instance, NKCC1 KO mice gradually became overweight, hyperinsulinemic, hyperglycemic, hypertriglyceridemic, glucose intolerant and insulin resistant while developing mild non-alcoholic steatohepatitis and reduced -cell mass and function, i.e., typical conditions found in MetS ( KO mice remain unresolved, it is evident that fundamental deficiencies in -cell function and/or mass are pivotal in the development/progression of age-dependent metabolic dysregulation (Hudish et al., 2019)

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Pataer A, Ozpolat B, Shao R, Cashman N, Plotkin S, Samuel C, Lin S, Kabil N, Wang J, Majidi M, Fang B, roth J, Vaporciyan AA, Wistuba I, Hung MC, Swisher SG