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Integrative omics analyses reveal that MYC orchestrates ammonium metabolism reprogramming in prostate cancer through direct transcriptional control of GLS, with TCGA-PRAD data confirming co-amplification of MYC and GLS (q 20 mM) impair immune cell function by competitively inhibiting monocarboxylate transporters (MCTs), MCT1 in T cells and MCT4 in NK cells, leading to metabolic paralysis or apoptosis (180) ( Figure 4 )

Braz J Microbiol 41:574580

This includes people with pernicious anemia, autoimmune disorders, or conditions that affect nutrient absorption

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This process releases iron, overwhelming FPN-mediated export and fueling ferroptosis

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