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00:03:55 Vickie Danaher And under normal conditions, when food enters the intestines, GLP-1 is released and triggers several important responses

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The metabolic effects of GLP-1 class medications operate around the clock regardless of injection timing

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SGLT2 Inhibitors The EMPA-REG OUTCOME and CANVAS studies have shown favourable all-cause mortality and cardiovascular outcomes.11,12 Meta-analyses of CVOTs confirmed the cardiovascular benefits.17,18 Three studies from landmark CVOTs further stratified patients according to baseline characteristics.21,22,23 The benefits of SGLT2 inhibitors were more apparent in patients with a history of HF and reduced ejection fraction.22,23 However, baseline risk was higher in this group of patients, possibly accounting for higher absolute risk reductions in cardiovascular outcomes

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