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[16] While some participants in clinical studies have reported menstrual changes, these are generally attributed to the metabolic effects of weight loss rather than direct drug action on reproductive tissues, and are not classified as common adverse effects in the UK product information for GLP-1 medications
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The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) ( 2.2 PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?
Both Mazdutide and Retatrutide may eventually receive approval for this indication, potentially helping millions of people with limited treatment options currently available
A licensed healthcare professional administers the injection in a few minutes
During this phase, 130 articles were excluded
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