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Combining separate single peptides risks solubility and stability problems and is not advised

FDA staff also noted that no adequate studies formally evaluated immunogenicity

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I asked James Peyer, Phd , who runs Cambrian Bio and advises here (hes building small-molecule longevity drugs, which makes him structurally skeptical), whats happening mechanistically with this specific bucket

Immunogenicity and allergic reactions

AOD-9604 vs MOTS-c: Side-Effect Profile Head-to-Head At a glance FDA approval status / Neither peptide is FDA-approved for any indication Head-to-head trials / None exist