Kinetic studies have shown that optimal cleavage rates occur between pH 75 and 85 and at 37C ( Reference Mentlein 45 )
If a patient is taking 0.5 mg subQ once weekly of injectable semaglutide, you should be able to switch them to oral semaglutide 7 mg or 14 mg daily
the most significant safety concerns are associated with high-dose, unregulated use in non-clinical settings
Side effects included nausea (44%), vomiting (24%), diarrhea (30%), constipation (24%), abdominal pain (20%), headache (14%), fatigue (11%), dizziness (8%), abdominal distension (7%), and belching (7%)
FEBS Lett 175: 3136
There are various reports of it being used for anti-aging purposes with the rationale that the aging process involves damage from free radicals and glutathione neutralizes the toxins and promotes healing and repair