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In a randomized controlled trial, 44 obese or overweight women treated with 80 mg of pyridoxine hydrochloride (a form of vitamin B6) for eight weeks experienced improved insulin sensitivity and decreased fat mass compared with placebo (Haidari 2021)
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Some individuals may experience light hypotension, occasional dizziness, or mild sedation, particularly when dosing is higher than optimal or poorly timed
Chemokines that contain the N-terminal motif preferred by DPP4 could serve as substrates for the enzyme, however, data demonstrates that not all chemokines that harbor the motif are acted upon by DPP4 in vivo
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