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10.4 Spatiotemporal dynamics of metabolic-immune crosstalk Microglial metabolic plasticity (e.g., M1 phenotype relying on glycolysis vs
And of course theres their original purpose: A highly effective medication to lower blood sugar and tackle Type 2 diabetes
It has demonstrated the ability to reduce body weight by more than 20% in individuals with obesity (118), and to improve glycemic control to a degree that 87-91% of enrolled individuals with type 2 diabetes reach HbA1c levels below the type 2 diabetes diagnostic threshold after 40 weeks of treatment (120)
Integrated multi-omics approaches have revealed metabolic heterogeneity in hypertrophic cardiomyopathy, enabling subtype-specific risk stratification and therapeutic strategies (70)
Cell Death Dis (2012) 3(11):e437
(2021) 19:e06768
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