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However, when APAP is ingested in excessive amounts, the capacity of GSH to neutralize NAPQI becomes overwhelmed, leading to depletion of hepatic GSH stores and accumulation of NAPQI, resulting in oxidative stress, mitochondrial dysfunction, and hepatocellular injury, ultimately culminating in acute liver injury and potential liver failure

& Schutt, F

Calcaterra, V., Verduci, E., Stagi, S., & Zuccotti, G

Informed consent Informed consent forms were obtained from all patients

Focus on lifestyle and nutrition changes If you cant get medication right away, dont underestimate the impact of lifestyle changes

Acta 1783 , 629640 (2008)