GPX5 does not contain selenium cysteine (Secys) at its active site, but instead uses cysteine residues (Cys) as its active site
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Moreover, GPX4 promotes immune evasion by inhibiting ferroptosis
Pharmacol Res - Modern Chin Med
Molecular Cancer Research, 12 (6), 924939
Thus, it has been reported that a two-pronged approach, utilizing both topical and oral nutraceutical supplementation, might be needed for optimal treatment of the skin