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Dual pH/light-responsive PEG-PDMAEMA-PNBAE micelles released curcumin at 46.5% under UV light at pH 5.5, protecting PC12 cells from A-induced apoptosis (138)

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11 An ongoing phase I/II clinical trial (NCT 04585750) has assessed the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of PC14586 administration in patients with advanced solid tumors harboring the p53 Y220C mutation