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Patients with a history of medullary thyroid carcinoma, personal or family history of multiple endocrine neoplasia type 2 (MEN2), or severe diabetic retinopathy should not use semaglutide
Godin B, Touitou E
Eli Lilly's orforglipron, a second type of GLP-1 pill, is still completing phase three trials, with results expected in the first quarter of 2026
This can lead to poor control of blood sugar levels in people with diabetes or reduced benefits in weight management
If insurance denial is likely, PlexusDx offers compounded semaglutide at $189/month with no insurance needed
These effects are typically worse when starting treatment or increasing doses
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