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In Phase 2 trials conducted by Eli Lilly and reported in the New England Journal of Medicine (2023), retatrutide was administered as a once-weekly subcutaneous injection, with doses escalating gradually over a structured titration schedule
As importantly, GLP-1 driven improvements in morbidity and mortality across so many conditions and patient populations strongly impacts the overall risk-reward calculation for prescribers considering a GLP-1 for a patient with SUD
9 , 11 One such intervention that warrants further investigation is the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs)
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