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Physiological replacement of GLP-1 by exogenous administration had little effect, but this may underestimate the role of endogenous GLP-1 for insulin secretion, because intravenous administration bypasses important hepato-portal sensors for GLP-1 [63]
Journal of Clinical Endocrinology & Metabolism , 91(3), 799-805
Trulicity (dulaglutide) is a GLP-1 receptor agonist used to treat type 2 diabetes
SURMOUNT-1 showed 22.5% mean body weight loss at 72 weeks with tirzepatide 15 mg [11]
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