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Gastroparesis and constipation are not the same thing, but the data show a parallel relationship for GLP-1 users

doi: 10.1056/NEJMoa2032183 9 WhartonSFreitasPHjelmesthJKabischMKandlerKLingvayIet al

If you start around 70 to 80 kg, 10 kg is a larger percentage, so it may take closer to 5 to 7 months for many people if you stay within a safe weekly rate and you protect muscle mass

The trajectory matters more than any single data point

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When folic acid builds up in the body, it can actually slow down the methylation cycle and even interfere with HNMT (histamine N-methyltransferase) , the enzyme that helps break down histamine