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Symptoms could include slight nausea, diarrhoea, or constipation

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In pediatric patients, diarrhea was also the most common adverse reaction in clinical trials of patients 7 to 17 years of age with IBS-C and 6 to 17 years of age with FC treated with LINZESS

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GH release during slow-wave sleep accounts for 70 to 80% of total daily GH output in healthy adults 17