Indeed, very recently we have employed the ERE-luciferase reporter mouse [196] to directly assess ER-mediated signalling following in vivo wounding [197]
For example, in the SURPASS-2 study, TZP at the dose of 5, 10, and 15 mg reduced HbA1c by -2.18% vs -1.86% with semaglutide and weight by -9.3 kg vs -5.7 kg
Eur J Pharmacol 752:7883 Ren J, Zhang N, Liao H, Chen S, Xu L, Li J, Yang Z, Deng W, Tang Q (2017) Caffeic acid phenethyl ester attenuates pathological cardiac hypertrophy by regulation of MEK/ERK signaling pathway in vivo and vitro
However, taking coffee by mouth may be safer and more effective : blood caffeine levels were 3.5x higher after drinking coffee than after an enema in a trial on 11 people [35+, 36, 37, 38, 39, 40, 41, 42, 43, 44]
Both forms work
Improved Skin Health : Sweating during a sauna session helps cleanse the skin, and glutathiones antioxidant properties can improve skin health by reducing inflammation and promoting a healthy, glowing complexion