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Half-life comparison: Retatrutide (~6 days) vs Tirzepatide (~5 days) vs Semaglutide (~7 days) Steady State: 4-5 Weeks Why steady state matters: Most drugs reach steady state after ~ 45 half-lives , which for retatrutide is about 45 weeks of weekly injections

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A 70 kg adult in Schneider-Helmerts protocol received approximately 1,485 mcg intravenously

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As a consequence, a G-6-PD Deficient specimen could be misclassified as NORMAL

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Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

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Thats when clinical experience stops being anecdotal

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10.1016/j.cell.2016.02.014 43 JangY.-Y.SharkisS

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