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Micronised formulations : These may dissolve more easily and potentially reduce gastrointestinal discomfort

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The ability of benfotiamine to inhibit three major pathways (the hexosamine pathway, the AGE formation pathway, and the diacylglycerol (DAG)-PKC pathway) simultaneously might be clinically useful in preventing the development and progression of diabetic complications

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Therefore, ALA is usually only considered in pregnancy if the potential benefit clearly outweighs any theoretical risk, and only under close medical supervision

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Other common abnormalities include reductions in intrinsic nerves and inhibitory neurons expressing nitric oxide synthase (NOS) [3, 6]

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