For example, PINK1 and Parkin loss of function impair mitophagy and cause accumulation of damaged mitochondria, leading to enhanced electron leakage and formation of superoxides 11,12,13
Unfortunately, glutathione levels decline with age, most specifically due to poor nutrition, stress, and to toxins from the environment
1 nM TGR was used in all assays
It combats the oxidative stress and cellular damage that contribute to aging and degenerative disease
Finally, partial inhibition of GSH may induce stress responses in cancer cells, leading to the upregulation of detoxifying enzymes and drug resistance
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