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Besides, Pt-generated O 2 (Pongjit and Chanvorachote, 2011) and OH (Sumkhemthong et al., 2021) might also play pivotal roles in the development of PIPN

Efficacy evidence

One unit of enzyme activity is the amount causing a change in absorbance of 0.001/min at 340 nm ( 2.18 Sorbitol dehydrogenase (SDH) and lactate dehydrogenase (LDH) The LDH assay is based on the inter-conversion of lactate and pyruvate and the SDH assay is based on inter-conversion of Fructose and Sorbitol

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At 24 weeks the 12 mg dose produced a mean relative reduction in liver fat of roughly 82%, with about 86% of participants on that dose reaching normal liver fat (under 5%), versus essentially no change on placebo

Stewart, M