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University of Oxford
Accordingly, GLP-1 RAs may at least partially share the pathway with ghrelin in stimulating GHRH/GH release
However, the relatively small differences with exendin-asp3 suggest that additional mechanisms beyond receptor trafficking may be involved in the blunted insulin secretory response with this compound
It also supports the brains ability to clear out metabolic waste that accumulates during the day
While there is no black box warning specifically forbidding the combination, the biological mechanisms of both substances overlap in ways that can be dangerous
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