This appetite-suppressing effect is thought to be mediated by the hypothalamus, a region of the brain involved in regulating hunger and energy balance
However, these tend to be dose dependent, self limiting, and transient once your body acclimates
Systemic hormone effects: GLP-1 receptors exist throughout the body, including in the heart, blood vessels, kidneys, and liver
The primary role of GLP-1 therapy in weight management is to assist patients in achieving and maintaining metabolic balance
Liu H, Dear AE, Knudsen LB, Simpson RW: A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules
Oral Semaglutide in Type 2 Diabetes: ClinicalMetabolic Outcomes and Quality of Life in Real-World Practice