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Moreover, increased serum chromium in smokers contributes to the production of O2 , H 2 O 2 , and OH [63, 157]

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reduced GABA signaling is linked to heightened anxiety Serotonin and dopamine influence mood regulation and motivation Glutamate drives excitatory signaling that, in excess, can fuel overactive stress circuits Chronic stress can also trigger low-grade neuroinflammation, a process increasingly tied to both anxiety and depression in clinical studies

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