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Neural stem cell differentiation into astrocytes and, at a lower extent, into new neurons is regulated by some factors such as bone marrow proteins (BMPs), whose expression is upregulated in the injury lesion after SCI (Wang et al., 2011

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Potential therapeutic targets are low-grade systemic inflammation, oxidative stress, NO signaling, RAAS signaling, ECM remodeling, calcification, VSMCs, and cellular senescence

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