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10.1186/s12882-017-0705-4 53 KurabayashiM

Treatment should be discontinued if less than 5% of body weight is lost after 6 months and is recommended for a maximum of 2 years

The primary concern relates to the potential risk of pulmonary aspiration due to delayed gastric emptying, as gastric contents could be regurgitated and aspirated into the lungs during sedation

SURMOUNT-1 results (72 weeks, adults with obesity): 5 mg dose: approximately 15% body weight loss 10 mg dose: 19.5% body weight loss 15 mg dose: 22.5% body weight loss Placebo: 3.1% body weight loss At the 15 mg maximum dose, the average participant lost about 52 pounds over 72 weeks

With supplements Creatine - Safe and potentially synergisticcreatine supports muscle energy while PEG-MGF supports repair

The SmPC also notes that rodent studies showed C-cell thyroid tumours, though the human relevance is unknown