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Dont extend cycles without supervision
In the SURPASS-2 study, the three doses of tirzepatide (5, 10, and 15 mg once weekly) were tested with the GLP-1RA semaglutide (1 mg once weekly) as a comparator in patients not optimally controlled on monotherapy with metformin (71)
Thats exactly what you want to prevent
Most discontinuations happen here (73% of those who quit do so during weeks 4-12)
Medication timing may be considered in consultation with a healthcare provider
doi:10.1016/S1701-2163(16)39370-7 Skelley JW, Swearengin K, York AL, Glover LH
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