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Mechanistic studies would be strengthened by isoform-specific NOS experiments, FAK or paxillin pathway inhibition, VEGFR2 pathway modulation, direct measurement of endothelial and fibroblast markers, and rescue experiments that test whether blocking one pathway prevents downstream effects

Patients using hydrocodone are often monitored closely for signs of dependency, and healthcare providers may recommend non-opioid alternatives or adjunct therapies to minimize risks while managing pain effectively

It interacts with multiple pathways, including those regulating angiogenesis, collagen synthesis, and inflammation

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16 weeks 112 syringes 1 syringe per day across 16 weeks