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"When you're off the drug, the food noise and hunger comes back." Prior to the trial, Rothenhoefer had been yo-yo dieting since age 13, and now felt like she was back in that vicious cycle, regaining 18 pounds in her year off of the medication

On the contrary, MC4R agonist, setmelanotide, was approved for the rare MC4R-deficiency, BardetBiedl syndrome (BBS), with severe obesity in childhood [10, 23]

The study was extended to 84 weeks to provide a longer runway for weight loss, for example

Always inform your healthcare provider if you're experiencing difficulties maintaining your injection schedule so they can offer practical support

Common issues include nausea, vomiting, diarrhea, and constipation, which are typically mild to moderate and most frequent during dose escalation

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