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This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates

Vaidya adds

Data are needed on the coadministration of cagrilintide and semaglutide (called CagriSema) for weight management in adults with type 2 diabetes, including those in a subgroup who are undergoing continuous glucose monitoring

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too little may not offer the desired therapeutic benefit