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Contact a healthcare professional promptly or seek urgent care for: Severe or persistent abdominal pain, especially pain radiating to the back Right-upper-abdominal pain accompanied by fever, vomiting, or yellowing of the skin or eyes Persistent vomiting or diarrhea Inability to keep fluids down Very little urination Fainting, severe weakness, confusion, or signs of significant dehydration Symptoms of severe hypoglycemia Rapidly worsening symptoms after a dose increase These symptoms may require physical examination, imaging, medication review, or immediate treatment rather than direct-to-consumer testing alone

In recent years, the landscape of weight-loss injections has shifted dramatically: from older GLP-1 medications to dual-agonists such as Mounjaro , and now to even more ambitious agents such as Retatrutide