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A systematic review of GLP-1 RA use in Alzheimers disease and related outcomes found that while preclinical studies (in animals) are strongly positive, human clinical data are limited
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Results Autocrine-based selection of a novel GLP-1R agonist To identify potential G-protein-biased ligands for the GLP-1R we expressed a peptide library at the cell surface of a reporter cell line co-expressing the GLP-1R and the green fluorescent protein (GFP) reporter gene under the control of a CRE promoter (HEK293-GLP-1R-GFP) to screen for peptides that induce GLP-1R-mediated cAMP production
Hudson, OH: Lexi-Comp, Inc
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