Starr MS, Starr BS, Kaur S
The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory
References Birchmeier, C., Birchmeier, W., Gherardi, E
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Rapid transit (diarrhoea-predominant IBS) similarly disrupts the stable microbiome balance required to outcompete yeast
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