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Ipamorelin's human data is limited to two published pharmacokinetic/pharmacodynamic studies: a 1999 PK/PD study (PMID: 10496658) that documented dose-response relationships and peak GH at 30-40 minutes post-injection in human volunteers, and a completed Phase II clinical trial for postoperative ileus (NCT00672074), after which ipamorelin's development for this indication was discontinued without approval

doi: 10.1038/s41589-025-01888-2 199 LiJZhanSYangWZhangHMaXChenFet al

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