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Klonoff DC, et al

Mice with skeletal-muscle specific deletion of the transferrin receptor, and thus iron deficiency in muscle, had impaired skeletal muscle metabolism but also developed a severe and lethal systemic metabolic phenotype with disappearance of fat pads and development of hepatic steatosis [121]

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Safety and efficacy of once-weekly semaglutide vs additional oral antidiabetic drugs in Japanese people with inadequately controlled type 2 diabetes: a randomized trial